Perianal Langerhans cell histiocytosis: case report and literature review

Revista Brasileira de Coloproctologia

Araújo, Mônica Leite de¹  Magno, Jaime Coelho Carlos¹  Magalhães, José Pinheiro¹  Nagel, Janaina²  Miranda, Cláudia Barreto de²  Pires, Vilmar José¹  D'Almeida, Dianice Gallo¹ 

[1] Hospital Estadual Getúlio Vargas;Hospital Estadual Getúlio Vargas, Rio de Janeiro, Brasil

关键词: langerhans cell histiocytosis;    X histiocytosis;    perianal histiocytosis;    langerhans cell;    and ulcer.;   

DOI  :  10.1590/S0101-98802007000100012

学科分类：心脏病和心血管学

来源: Sociedade Brasileira de Coloproctologia

【 摘 要 】

A rare case of Langerhans cell histiocytosis with perianal involvement in a 34 year old white man is presented. During nineteen months this patient had a complaint of anal pain with bleeding, due to a large perianal ulcer. The initial diagnosis was Crohn's disease, anal tuberculosis, syphilis, pyoderma gangrenosum or donovanosis. After the third biopsy, the surgical specimens showed microscopic changes suggestives of Langerhans cell histiocytosis. The imunohistochemical study was positive to S100 protein and CD1a. The patient was treated with six doses of intralesional triancinolona and oral thalidomide for three months. Treatment was well tolerated and complete resolutions of peri-anal ulcer occurred.

【 授权许可】

CC BY-NC