The fate and tissue disposition of deoxynivalenol in broilerchickens

Journal of Veterinary Medical Science

Saranya POAPOLATHEP³  Susumu KUMAGAI¹  Phanwimol TANHAN³  Supaporn ISARIYODOM²  Amnart POAPOLATHEP³  Kanjana IMSILP³  Sasithorn PRALATNET³ 

[1] Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113�?8657, Japan;Department of Animal Science, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand;Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand

关键词: broiler;    deoxynivalenol;    fate residue;    residue broilers;   

DOI  :  10.1292/jvms.14-0676

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(33)Cited-By(2)To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered eitherintravenously or orally to broilers at a dose of 1 mg/kg BW. Concentrations of DON inplasma were measurable up to 4 hr and 2 hr after intravenous and oral administration,respectively. Following intravenous administration, the values for the eliminationhalf-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03l/kg and 4.16 ± 0.42 l/hr/kg, respectively. The oralbioavailability was 15.46 ± 4.02%. DON was detectable in all tissues examined after oraladministration. These results suggest that DON is able to penetrate into the varioustissues in broilers, though poorly absorbed from their gastrointestinal tract.

【 授权许可】

Unknown