Axillary Irradiation as an Imperative Alternative to Axillary Dissection in Clinically Lymph Node-Negative but Sentinel Node-Positive Breast Cancer Patients?

Breast care

Robert Hermann¹  Mirko Nitsche¹ 

[1] aZentrum für Strahlentherapie und Radioonkologie, Ärztehaus am DIAKO, Bremen, Germany

关键词: Adjuvant treatment;    Breast cancer;    Curative radiotherapy;    Sentinel lymph node;   

DOI  :  10.1159/000333835

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

At the moment, positive sentinel lymph node dissection (SLND) of the axilla is followed by axillary lymph node dissection (ALND) as standard of care. Recent data proves that omitting ALND after positive SLND in clinically lymph node-negative early stage breast cancer patients is feasible with low recurrence rates. The well known effect of radiotherapy to destroy occult tumor cells highly contributes to these results as a large extent of level I and II lymph nodes are unavoidably included in standard tangential radiation treatment fields. Reviewing the up to date published data on axillary lymph node treatment with radiotherapy, we hypothesize that full dosage coverage of level I and II of the axilla in early stage breast cancer will improve outcome and should be further evaluated.

【 授权许可】

Unknown