Long-Term Survival in a Dog with Anaplastic Oligodendroglioma Treated with Radiation Therapy and CCNU

Journal of Veterinary Medical Science

Takayuki KUWABARA¹  Kazuyuki UCHIDA²  Shunta MIZOGUCHI¹  Michio FUJITA¹  Daisuke HASEGAWA¹  Naoko YAYOSHI³ 

[1] Division of Veterinary Radiology, Department of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyounan-cho, Musashino-shi, Tokyo 180–8602, Japan;Department of Veterinary Pathology, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan;The Animal Medical Center, Department of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyounan-cho, Musashino-shi, Tokyo 180–8602, Japan

关键词: canine;    CCNU;    MRI;    glioma;    radiation therapy;   

DOI  :  10.1292/jvms.12-0058

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(1)A 9 year-old, neutered, male French Bulldog showing cluster seizures was diagnosed with a glioma in the right piriform cortex by MRI. Hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the lesion had involuted significantly at 2 months after RT, recurrence was observed at 4 months after RT. Chemotherapy was started using CCNU (60 mg/m2 every 6–9 weeks) and was continued for one year. Follow-up MRI revealed involution of the lesion and the intervals of CCNU were increased to every 9–14 weeks. Two years after the first presentation, the dog suffered status epilepticus, followed by deficits of left sided postural reaction with cognitive dysfunction. The dog died on day 910, and histopathological diagnosis confirmed anaplastic oligodendroglioma.

【 授权许可】

Unknown