Anaplastic oligodendroglioma with leptomeningeal dissemination in a french bulldog

The Journal of Veterinary Medical Science

Kazuyuki UCHIDA¹  Daisuke FUKUNAGA²  Takuya KISHIMOTO³  Takashi MORI⁴  Yuya NAKAMOTO⁵ 

[1] Crea Animal Hospital, 5-13-21, Aoyama, Otsu, Shiga 520-2101, Japan;Department of Bioartificial Organs, Institute for Frontier Life and Medical Sciences, Kyoto University, 53, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan;Department of Veterinary Pathology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;Kyoto Animal Referral Medical Center, 208-4, Shinarami, Tai, Kumiyama-cho, Kuze-gun, Kyoto 613-0036, Japan

关键词: canine;    glioma;    leptomeningeal dissemination;    MRI;    treatment;   

DOI  :  10.1292/jvms.17-0652

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A 2.5-year-old male French Bulldog was evaluated for seizures. Cranial magnetic resonance imaging (MRI) suggested a glioma in the left piriform area. Radiation therapy (RT) and continuous chemotherapy were administered. Although the lesion had regressed significantly 2 months after RT, a follow-up MRI revealed meningeal enhancement in the left piriform area, which expanded further, with hydrocephalus, by day 310 (8 months after RT). Because of the poor prognosis, the dog was euthanized on day 356 and necropsy was performed. Histopathological examination confirmed anaplastic oligodendroglioma with leptomeningeal dissemination. This case suggests that the possibility of leptomeningeal dissemination and hydrocephalus should be considered even after RT and chemotherapy for anaplastic oligodendroglioma.

【 授权许可】

Unknown