Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Clinical Molecular and Genetic Studies on Alzheimer’s Disease

Journal of Pharmacological Sciences

Mikio Shoji¹ 

[1] Department of Neurology, Hirosaki University Graduate School of Medicine, Japan

关键词: Alzheimer’s disease;    mild cognitive impairment;    amyloid β (Aβ);    tau;    biomarker;   

DOI  :  10.1254/jphs.11R13FM

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(33)Cited-By(5)Recent advances in clinical molecular and genetic studies on Alzheimer’s disease (AD) are summarized here. Cerebrospinal fluid (CSF) Aβ42 and tau are the most sensitive biomarkers for the diagnosis of AD and prediction of its onset following mild cognitive impairment (MCI). Based on this progress, new diagnostic criteria for AD dementia, MCI due to AD, and preclinical AD were proposed by the National Institute of Aging (NIA) and Alzheimer’s Association (AA) in April 2011. In these new criteria, progress in CSF biomarker and amyloid imaging studies over the past 10 years has added to critical information. The marked contributions of basic and clinical studies have established clinical evidence supporting these markers. Based on this progress, essential curative therapy for AD is urgently expected.

【 授权许可】

Unknown