Involvement of the Na+/Ca2+ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400

Journal of Pharmacological Sciences

Hikaru Tanaka¹  Iyuki Namekata¹  Kiyoshi Takeda¹  Takahiko Sugimoto¹  Midori Nagaharu¹  Toru Kawanishi²  Hideaki Shimada¹  Akira Takahara¹  Koki Shigenobu¹  Yayoi Tsuneoka¹ 

[1] Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan;Division of Drugs, National Institute of Health Sciences, Japan

关键词: pulmonary vein myocardium;    Na+/Ca2+ exchanger;    automaticity;   

DOI  :  10.1254/jphs.08159SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(17)Cited-By(20)We examined the involvement of the Na+/Ca2+ exchanger in the automaticity of the pulmonary vein myocardium with a specific inhibitor, SEA0400. Action potentials were recorded from the myocardial layer of isolated guinea-pig pulmonary vein preparations, and Ca2+ transients were recorded from the cardiomyocytes. Spontaneous electrical activity was observed in 17.7% of the preparations, which was inhibited by either SEA0400 or ryanodine. In quiescent preparations, ouabain induced electrical activity and spontaneous Ca2+ transients, which were inhibited by SEA0400, as well as ryanodine. These results provide pharmacological evidence that the Na+/Ca2+ exchanger underlies the automaticity of the pulmonary vein myocardium.

【 授权许可】

Unknown