Electrical Activity of the Mouse Pulmonary Vein Myocardium

Journal of Pharmacological Sciences

Hikaru Tanaka¹  Iyuki Namekata¹  Yuka Kobayashi¹  Yoriko Honda¹  Yayoi Tsuneoka¹ 

[1] Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan

关键词: pulmonary vein myocardium;    automaticity;    autonomic neurotransmitter;   

DOI  :  10.1254/jphs.12062SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(7)We recorded the electrical activity from the myocardial layer of isolated mouse pulmonary veins with the glass microelectrode technique. Spontaneous electrical activity was observed in about half of the preparations, which appeared either as constant firing or as repetitive bursts. Noradrenaline enhanced, while acetylcholine reduced, automatic activity. The action potentials evoked in quiescent preparations showed a resting membrane potential less negative than the atria and an extremely rapid early repolarization followed by a late plateau. The present study revealed that the mouse pulmonary vein myocardium shows diverse electrical activity, which is influenced by autonomic neurotransmitters.

【 授权许可】

Unknown