Anticonvulsant Effect of Pitavastatin in Mice Induced by Pentylenetetrazole | Science Publications

American Journal of Animal and Veterinary Sciences

Khayatnouri Mirhadi¹ 

关键词: Threshold;    Franeyltransferase Inhibitor (FTI);    neurological diseases;    PTZ-induced seizure;    elevated serum;    lipid-lowering;    control group;    seizure threshold;   

DOI  :  10.3844/ajavsp.2011.166.170

学科分类：兽医学

来源: Science Publications

【 摘 要 】

Problem statement: The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipid-lowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of pitavastatin on PTZ-induced seizure threshold in mice. Approach: Mice were divided into 9 groups randomly: the first group received saline normal (ip) (control group); the second group received Carboxymethylcellulose (CMC) 0.5% (ip) (vehicle group) and the next groups received respectively different doses of pitavastatin (1, 5, 10, 20, 40, 80 and 100 mg kg daily^-1) for 4 days (ip) before determination of seizure threshold induced by PTZ. Results: Results showed that PTZ-induced seizure threshold in control mice was 35.48

【 授权许可】

Unknown