Structure and Properties of Members of the hGH Family

Endocrine Journal

URBAN J. LEWIS¹  GEOFFREY P. LEWIS²  YAGYA N. SINHA¹ 

[1] Neuroscience Institute, University of California Santa Barbara

关键词: Growth hormone;    Variants;    Diabetes;    Retinopathy;   

DOI  :  10.1507/endocrj.47.SupplMarch_S1

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(22)This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20 KD-hGH, and two peptides made up of portions of 22 KD-hGH. The two pituitary peptides (hGH1-43 and hGH44-191) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The shorter peptide may prove to be useful in decreasing the amount of exogenous insulin required by diabetics. The larger, strongly anti-insulin peptide, may be involved in diabetic retinopathy. We believe that this peptide is the long sought after diabetogenic substance of the pituitary gland.

【 授权许可】

Unknown