Galanin-like Immunoreactive Neural Elements in Domestic Ruminant Pancreas

Journal of Veterinary Medical Science

Emmanuel T. BALTAZAR³  Hazel Marie R. BOLORON¹  David F. COTTRELL²  Nobuo KITAMURA³  Junzo YAMADA³  Motoki SASAKI³ 

[1] Department of Veterinary Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Central Mindanao University;Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, University of Edinburgh;Department of Veterinary Anatomy, Obihiro University of Agriculture and Veterinary Medicine

关键词: galanin;    immunohistochemistry;    pancreas;    ruminant;   

DOI  :  10.1292/jvms.63.841

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(2)The distribution and ontogeny of the galanin-like immunoreactive (Gal-IR) neural structures in the pancreas of cattle, sheep and goat were investigated immunohistochemically. The present study confirmed the previous findings on the immunolocalization of galanin both in the neural elements and endocrine cells of cattle, and reported for the first time its exclusive localization in the neural elements of sheep and goat. The frequency of Gal-IR nerve fibers and nerve cell bodies was high in cattle and low in sheep and goat. Their first detection was at the first fetal trimester in cattle and third trimester in sheep and goat. In cattle, a marked increase in the frequency of Gal-IR nerve fibers was observed from the third trimester to early neonatal stage followed by a decrease after three months postnatal. In contrast to the non-preferential distribution pattern in sheep, the Gal-IR nerve fibers in cattle and goat pancreas were predominantly associated with the acini, excretory ducts and blood vessels, but rarely detected in the pancreatic islets. The Gal-IR nerve cell bodies were observed as isolated bodies in the intra-and interlobular connective tissues and as a group within the intrapancreatic ganglia. At the vicinity of the nerve cell bodies, Gal-IR nerve fibers were observed. The present findings may suggest that: (1) galanin regulates pancreatic function as neurotransmitter/neuromodulator in ruminants; (2) galanin plays a more important role in large than in small ruminants; and (3) particularly in cattle, it exerts its most dramatic effect during perinatal development.

【 授权许可】

Unknown