Protective Immunity against Multiple Challenges of Brugia pahangi in Mongolian Gerbils Induced by Drug-Abbreviated Infection

Journal of Veterinary Medical Science

Susumu MAKIMURA¹  Yoichiro HORII¹ 

关键词: Brugia pahangi;    Meriones unguiculatus;    protection;   

DOI  :  10.1292/jvms.56.803

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Protective immunity against multiple challenge infections was examined in Mongolian gerbils after a drug-abbreviated infection with Brugia pahangi. The gerbils treated with mebendazole (MBZ) during the late prepatent period (7-9 weeks of postinfection) were challenged with 5 inoculations of 50 infective larvae of B. pahangi at 4-week intervals. The worm burden was significantly reduced 68.6% (19.0 in average number) to that of controls (60.6) and was accompanied with enhanced eosinophil responses 1 week after each challenge. MBZ-treated gerbils suppressed microfilaremia almost completely after the challenge infections.

【 授权许可】

Unknown