Methadone and Dexmedetomidine Combination as Premedicant Agents for Ovariectomy in Cats | Science Publications

American Journal of Animal and Veterinary Sciences

I. Vannozzi¹  G. Breghi¹  H. Tayari¹  A. Briganti¹ 

关键词: Methadone;    Dexmedetomidine;    Sedation;    Ovariectomy;    Cat;   

DOI  :  10.3844/ajavsp.2015.101.111

学科分类：兽医学

来源: Science Publications

【 摘 要 】

The purpose of this study was to assess sedative andanalgesic effects produced by the association of methadone and dexmedetomidine,administered intramuscularly as premedication for ovariectomy in cats.Twenty-four healthy cats were enrolled in the study. The values of heart andrespiratory rate were recorded as Tbase. Cats received methadone 0.5 mg kg^-1 and dexmedetomidine 5 mcg kg^-1 IM. Sedation and ease for catheterizationwere scored using a simple descriptive scale ranging from 0 (no sedation) to 3(profound sedation) and 0 (very difficult) to 3 (very easy). General anesthesiawas induced with propofol and after endotracheal intubation it was maintainedwith isoflurane. During the surgery Heart Rate (HR), Respiratory Rate (RR),hemoglobin oxygen saturation, Doppler blood pressure, expiratory isofluranepercentage and end tidal of carbon dioxide were recorded every five minutes. Atthe end of the surgery all animals received robenacoxib 2 mg kg^-1 subcutaneously. Recovery wasscored using a simple descriptive scale ranging from 0 (poor) to 3 (excellent).The median sedation score was 2 (range 0-3); the only adverse effect associatedwith the premedication was vomiting occurred in 20% of the cats. No animalsbecame excited after premedication. The median ease for catheterization was 3(range 1-3). After premedication HR and RR showed a decrease of 28% and of 32%,respectively, in comparison to Tbase values. The median recovery score was 3(range 1-3). No animal required additional analgesia after the surgery. Theassociation of dexmedetomidine 5 mcg kg^-1 and methadone 0.5 mg kg^-1 employed in this study resultedin overall good sedation quality without any major adverse reaction. The onsetof sedation was quite fast (about 7 min), suggesting synergic effect of the twomolecules. Most of cats showed an easy catheterization and the recovery wasexcellent for the majority of cases.

【 授权许可】

Unknown