The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury

Journal of Pharmacological Sciences

Takashi Kudo⁴  Masahiro Ikeda¹  Hiroko Sonoda¹  Kazunori Imaizumi³  Naoko Yokota-Ikeda²  Worapat Prachasilchai¹  Katsuaki Ito¹ 

[1] Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan;Nephrology Division, Miyazaki Prefectural Miyazaki Hospital, Japan;Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Japan;Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Japan

关键词: renal ischemia-reperfusion injury;    endoplasmic reticulum (ER) stress;    unfolded protein response;   

DOI  :  10.1254/jphs.08272SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(12)Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.

【 授权许可】

Unknown