Full Genome Sequence and Virulence Analyses of the Recent Equine Isolate of Japanese Encephalitis Virus

Journal of Veterinary Medical Science

Masayuki SHIMOJIMA¹  Takashi YAMANAKA²  Seiji TAMARU¹  Ken MAEDA¹  Hiroshi SHIMODA¹  Tomio MATSUMURA²  Takashi KONDO²  Yumiko NAGAO¹ 

[1] Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University;Epizootic Research Center, Equine Research Institute, Japan Racing Association

关键词: genotype;    horse;    Japanese encephalitis virus;    sequence;    virulence;   

DOI  :  10.1292/jvms.10-0502

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(4)In the past 25 years, there has been only one case of Japanese encephalitis in horses in Japan. We determined the full genome sequence of the Japanese encephalitis virus (JEV) strain JEV/eq/Tottori/2003 isolated from an afflicted horse and also analyzed its virulence in mice. The sequence analysis showed that the genome of JEV/eq/Tottori/2003 is similar to that of genotype I, a dominant genotype of JEV presently circulating in Japan. Its neurovirulence, but not neuroinvasiveness, was still as high as it was for genotype III, thus indicating the necessity for continuation of a vaccination program of horses against JEV.

【 授权许可】

Unknown