Pedigree Analysis of Factor XI Deficiency in Japanese Black Cattle

Journal of Veterinary Medical Science

Masaki TAKASU²  Naohito NISHII²  Hitoshi KITAGAWA¹  Tetsuo KUNIEDA³  Yasunori OHBA¹  Eri TAKEDA¹  Sadatoshi MAEDA¹ 

[1] Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University;Department of Clinical Veterinary Medicine, United Graduate School of Veterinary Sciences, Gifu University;Graduate School of Natural Science and Technology, Okayama University

关键词: factor XI deficiency;    gene frequency;    Japanese black cattle;   

DOI  :  10.1292/jvms.70.297

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Cited-By(5)Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cattle with the factor XI deficiency. Results showed that the mutated allele of factor XI deficiency was retroactive in at least 6 or more generations of sires. Frequencies of the mutant gene were higher at 26.4% in total, and at 33.3% in sires. All 7 cattle with the homozygote of mutated allele were clinically normal, and showed no bleeding episodes. The mutated allele of factor XI deficiency might be widespread among Japanese black cattle.

【 授权许可】

Unknown