Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Journal of Veterinary Medical Science

Seiichi KAWAMURA²  Takaaki ANDO²  Yoshikazu SUGIMOTO¹  Hiromichi OHTSUKA²  Tetsuo KUNIEDA⁴  Takashi HIRANO¹  Shogo ABE³  Yoshimi OGATA³  Daisaku WATANABE² 

[1] Shirakawa Institute of Animal Genetics;School of Veterinary Medicine and Animal Sciences, Kitasato University;NOSAI Yamagata Veterinary Training Center;Graduate School of Natural Science and Technology, Okayama University

关键词: claudin-16 deficiency;    factor XI deficiency;    growth retardation;    hypogenesis;    Japanese Black cattle;   

DOI  :  10.1292/jvms.68.1251

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(6)Blood examinations and genotyping of Factor XI (F11) were performed in growth retardation Japanese Black cattle and their dams. Genotyping of F11 revealed that the recessive homozygous and heterozygous genotype frequencies were 5.2% and 50.0% in the Claudin-16 (CL-16) deficiency group (n=58), 0% and 14.2% in the renal dysplasia group (n=7), 0% and 26.1% in the non-CL-16 deficiency nephritis group (n=23), 8.9% and 46.7% in the hypogenesis syndrome group (n=45), 6.2% and 25.0% in the neonatal weak calf syndrome group (n=32), 9.1% and 38.6% in the respective dams group (n=44), 0% and 23.1% in the normal cattle group (n=13), and 5.9% and 38.2% in total (n=222), respectively. These results showed that the carrier rate of F11 deficiency was high in Japanese Black cattle, and that the CL-16 deficiency, hypogenesis syndrome, neonatal weak calf syndrome, and dams groups had a large amount of recessive homozygous genotype than the other groups. No abnormal bleeding was observed clinically in the present study, and 4 of the recessive homozygous dams showed normal growth and parturition.

【 授权许可】

Unknown