Generation of Antiviral CD11ahigh T Cells in CD4+ T Cell-Depleted Mice and Adult Thymectomized Mice after Mouse Hepatitis Virus Infection

Journal of Veterinary Medical Science

Kenji MACHII¹  Shigeru KYUWA¹  Atsushi OKUMURA¹ 

关键词: CD11a;    mouse hepatitis virus;    thymus;   

DOI  :  10.1292/jvms.58.465

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(9)The mechanism of CD11ahighCD8+ T cell induction after mouse hepatitis virus infection, which has been suggested to play a key role in the elimination of infectious virus from the spleen in C57BL/6 mice, was studied. In CD4+ T cell-depleted mice, CD11ahighCD8+ T cells were induced in the spleen and spleen cells showed virus-specific cytotoxic T lymphocyte activity after mouse hepatitis virus Infection. The same results were obtained in adult thymectomized mice. These results indicate that CD11ahighCD8+ T cells can be generated after mouse hepatitis virus infection in the absence of either CD4+ T cells or the thymus.

【 授权许可】

Unknown