Journal of Veterinary Medical Science | |
Generation of Antiviral CD11ahigh T Cells in CD4+ T Cell-Depleted Mice and Adult Thymectomized Mice after Mouse Hepatitis Virus Infection | |
Kenji MACHII1  Shigeru KYUWA1  Atsushi OKUMURA1  | |
关键词: CD11a; mouse hepatitis virus; thymus; | |
DOI : 10.1292/jvms.58.465 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(9)The mechanism of CD11ahighCD8+ T cell induction after mouse hepatitis virus infection, which has been suggested to play a key role in the elimination of infectious virus from the spleen in C57BL/6 mice, was studied. In CD4+ T cell-depleted mice, CD11ahighCD8+ T cells were induced in the spleen and spleen cells showed virus-specific cytotoxic T lymphocyte activity after mouse hepatitis virus Infection. The same results were obtained in adult thymectomized mice. These results indicate that CD11ahighCD8+ T cells can be generated after mouse hepatitis virus infection in the absence of either CD4+ T cells or the thymus.
【 授权许可】
Unknown
【 预 览 】
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RO201911300586688ZK.pdf | 450KB | download |