Modeling morphological instabilities in lipid membranes with anchored amphiphilic polymers

Journal of Chemical Biology

F. Campelo¹ 

[1] Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), Doctor Aigüader, 88. 08003 Barcelona, Spain

关键词: Lipid bilayer;    Morphological instability;    Curvature;    Bending phase-field models;   

DOI  :  10.1007/s12154-009-0020-z

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Anchoring molecules, like amphiphilic polymers, are able to dynamically regulate membrane morphology. Such molecules insert their hydrophobic groups into the bilayer, generating a local membrane curvature. In order to minimize the elastic energy penalty, a dynamic shape instability may occur, as in the case of the curvature-driven pearling instability or the polymer-induced tubulation of lipid vesicles. We review recent works on modeling of such instabilities by means of a mesoscopic dynamic model of the phase-field kind, which take into account the bending energy of lipid bilayers.

【 授权许可】

Unknown