Endemic Goiter in the Jos Plateau Region of Northern Nigeria

Endocrine Journal

ABAYAMI IBIDAYA BANWO³  ISAO MORIMOTO²  JOHN ONYEANI EGBUTA³  SHIGENOBU NAGATAKI¹  SONTASH CHANDRA DAS³  UCHE PETER ISICHEI³ 

[1] First Department of Internal Medicine, Nagasaki University School of Medicine;First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health;Department of Clinical Chemical Pathology, Faculty of Medical Science, University of Jos

关键词: Endemic goiter;    Iodine;    Iodine deficiency;    Thiocyanate;    Thyroxine binding globulin (TBG);   

DOI  :  10.1507/endocrj.42.23

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(26)Cited-By(3)This study is an endemic goiter survey of 3476 school children in 13 Local Government Councils (LGCs) and 1004 subjects in a whole community of one LGC, Plateau State, Northern Nigeria, to determine the prevalence of goiter as well as to identify some of the etiological agents involved. Results of the survey showed that the disease is highly endemic in the area with prevalence varying in places from 1 to 23% of these subjects. Females showed a markedly higher prevalence of goiter. Analysis of 729 urine samples indicated that iodine excretion ranged from 3.5 to 15.3μg/dl (32-154μg/g creatinine) and was similar to that in iodine deficient areas in the world, but no relation was observed between the prevalence of goiter and urinary iodine. Urinary thiocyanate levels were less than 0.5mg/dl, suggesting that the role of thiocyanate as a goitrogen is not important in the region. Thyroid hormone parameters in village subjects with goiter were similar to those in goiter endemia except serum thyroxine (T4). An interesting result found in village subjects was very high serum thyroxine binding globulin, which leads to an increase in serum T4. This study indicated that Northern Nigeria is an area of endemic goiter. Although some areas in Plateau State are iodine deficient zones, we could not conclude that the etiology of endemic goiter in this area is associated with iodine deficiency. There may be an interplay of multiple factors of etiological importance.

【 授权许可】

Unknown