Rapid absorption of diclofenac and acetaminophen after their oraladministration to cattle

Journal of Veterinary Medical Science

Kazuaki SASAKI¹  Masato NAGASUE²  Akiyo SAWAGUCHI¹  Keisuke MIYANAGA¹  Minoru SHIMODA¹  Mitsuhiro NAKAYAMA¹ 

[1] Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183�?8509, Japan;Meiji Seika Pharma, Co., Ltd., Chuo, Tokyo 104�?8002, Japan

关键词: acetaminophen;    cattle;    diclofenac;    oral absorption;    pharmacokinetics;   

DOI  :  10.1292/jvms.16-0202

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasmaconcentration-time data after its intravenous and oral administration in order to proposethe oral administration of DF as effective route to avoid long withdraw period. DF wasintravenously and orally administered at 1 mg/kg to cattle using a crossover design with a4-week washout period. Plasma concentrations of DF were determined by a HPLC analysis. Themean absorption time (MAT) and absorption half-life (t1/2ka) were 1.61 ± 0.61and 1.51 ± 0.38 hr, respectively, and bioavailability was nearly 100%. The oralpharmacokinetics of acetaminophen (AAP) were also evaluated in cattle. Plasmaconcentrations of AAP were determined by a HPLC analysis. MAT and t1/2ka were2.85 ± 0.93 and 1.53 ± 0.28 hr, respectively, and bioavailability was approximately 70%.In conclusion, the results of the present study indicate that DF and AAP are rapidlyabsorbed from the forestomach of cattle. Therefore, the appropriate efficacies of thesedrugs may be achieved via their oral administration, even in cattle.

【 授权许可】

Unknown