Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats

Journal of Veterinary Medical Science

Kazuaki SASAKI³  Waleed Fathy KHALIL¹  Yuji MIYAZAKI³  Mohamed ELBADAWY³  Mohamed ABOUBAKR²  Minoru SHIMODA³ 

[1]Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt

[2]Pharmacology Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, 13736, Egypt

[3]Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183�?8509, Japan

关键词: acetaminophen;    gastric emptying;    goat;    oral absorption;    pharmacokinetics;   

DOI  :  10.1292/jvms.15-0104

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(1)The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba goats in order to evaluate the properties of gastric emptying. Acetaminophen was intravenously and orally administered at 30 mg/kg body weight to goats using a crossover design with a 3-week washout period. The stability of acetaminophen in rumen juice was also assessed. Acetaminophen concentrations were measured by HPLC. Since acetaminophen was stable in rumen juice for 24 hr, the extremely low bioavailability (16%) was attributed to its hepatic extensive first-pass effect. The mean absorption time and absorption half-life were unexpectedly short (4.93 and 3.35 hr, respectively), indicating its marked absorption from the forestomach, which may have been due to its smaller molecular weight. Therefore, acetaminophen was considered to be unsuitable for evaluating gastric emptying in Shiba goats.

【 授权许可】

Unknown