Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone–Treated Rats

Journal of Pharmacological Sciences

Kouhei Kitagawa²  Kazuhiko Shibata¹  Hidenori Sagara¹  Hiromu Kawasaki³  Shizue Kimoto¹  Toshiaki Sendo¹  Yoshihisa Kitamura²  Yutaka Gomita¹ 

[1] Department of Hospital Pharmacy, Okayama University Medical School, Japan;Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan;Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

关键词: selegiline;    monoamine oxidase-B;    treatment-resistance depression;    forced swim test;    dopamine D3 receptor;   

DOI  :  10.1254/jphs.FP0072150

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(25)Cited-By(6)In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D3–receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D3 receptor.

【 授权许可】

Unknown