Journal of Pharmacological Sciences | |
Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone–Treated Rats | |
Kouhei Kitagawa2  Kazuhiko Shibata1  Hidenori Sagara1  Hiromu Kawasaki3  Shizue Kimoto1  Toshiaki Sendo1  Yoshihisa Kitamura2  Yutaka Gomita1  | |
[1] Department of Hospital Pharmacy, Okayama University Medical School, Japan;Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan;Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan | |
关键词: selegiline; monoamine oxidase-B; treatment-resistance depression; forced swim test; dopamine D3 receptor; | |
DOI : 10.1254/jphs.FP0072150 | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(25)Cited-By(6)In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D3–receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D3 receptor.
【 授权许可】
Unknown
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