Development of Streptococcus agalactiae vaccines for tilapia

Diseases of Aquatic Organisms

Wei Zhang¹  , Kangming Chen¹  ,, Jielian Zhu¹  Tingting Gao¹  Yongjie Liu¹  Guangjin Liu¹  Huochun Yao¹  Chengping Lu¹ 

关键词: Streptococcus agalactiae;    Nile tilapia;    Oreochromis niloticus;    Vaccine;    Relative percent survival;    Adjuvant;   

DOI  :  10.3354/dao03084

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: Vaccination is a widely accepted and effective method to prevent most pathogenic diseases in aquaculture. Various species of tilapia, especially Nile tilapia Oreochromis niloticus, are farmed worldwide because of their high consumer demand. Recently, the tilapia-breeding industry has been hampered by outbreaks of Streptococcus agalactiae infection, which cause high mortality and huge economic losses. Many researchers have attempted to develop effective S. agalactiae vaccines for tilapia. This review provides a summary of the different kinds of S. agalactiae vaccines for tilapia that have been developed recently. Among the various vaccine types, inactivated S. agalactiae vaccines showed superior protection efficiency when compared with live attenuated, recombinant and DNA vaccines. With respect to vaccination method, injecting the vaccine into tilapia provided the most effective immunoprotection. Freund’s incomplete adjuvant appeared to be suitable for tilapia vaccines. Other factors, such as immunization duration and number, fish size and challenge dose, also influenced the vaccine efficacy.

【 授权许可】

Unknown