The Antioxidative Effects of Astragalus Saponin I Protect Against Development of Early Diabetic Nephropathy

Journal of Pharmacological Sciences

Jun Qiu¹  Yindi Zhang¹  Pei Zhang¹  Jianping Shen¹  Haiwei Wu²  Xiang Zhu²  Xiaoxing Yin¹  Junxian Yu¹ 

[1] Department of Pharmacology, Nanjing Medical University, China;Department of Pathogenic Biology, Nanjing Medical University, China

关键词: Astragalus saponin I;    diabetic nephropathy;    antioxidative;    mesangial cell;   

DOI  :  10.1254/jphs.FP0050041

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(28)Cited-By(21)It has been known that oxidative stress plays an important role in the development of diabetic nephropathy (DN). The antioxidative effects of Astragalus saponin I (AS I) were studied in vitro and in vivo. In the presence of high glucose and H2O2, the total antioxidative capability, catalase, reduced glutathione, and superoxide dismutase level of rat mesangial cells were significantly decreased, and transforming growth factor β1 (TGF-β1) mRNA level, collagen IV, and laminin level were significantly increased. When compared with those in the high glucose group, these 4 indexes of cells incubated in 2.0 and/or 20 μmol/L of AS I were significantly enhanced, and levels of TGF-β1 mRNA, collagen IV and laminin were statistically decreased. By flowcytomery, percentages of S phase of cells incubated in high glucose and H2O2 were lowered, while those in AS I were increased. Furthermore, the physical behaviors of rats treated with 12 mg/kg of AS I restored with vigor and weight gaining, while the level of HbAlC was significantly reduced. Thus, AS I has antioxidative effects and is a potential compound worth further study because it may prevent the development of DN.

【 授权许可】

Unknown