The Inhibitory Effects of Aqueous Extract of Magnolia officinalis on Human Mesangial Cell Proliferation by Regulation of Platelet-Derived Growth Factor-BB and Transforming Growth Factor-β1 Expression

Journal of Pharmacological Sciences

Ho-Kyung Doo³  Sang-Ho Lee¹  Jae-Kyung Park⁵  Se-Young Ahn³  Seung-Jae Hong¹  Hee-Jae Lee²  Sung-Do Kim¹  Sheng-Yu Jin²  Kang-Hyun Leem⁴  Byung-Cheol Lee³  Joo-Ho Jung² 

[1] East West Medical Center, Kyung Hee University;Department of Pharmacology, College of Medicine, Kyung Hee University;Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University;College of Oriental Medicine, Semyung University;WHO Collaborating Center of Traditional Medicine, Kyung Hee University

关键词: Magnolia officinalis;    mesangial cell;    proliferation;   

DOI  :  10.1254/jphs.94.81

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)Mesangial cell (MC) proliferation, mediated by platelet-derived growth factor (PDGF)-BB, transforming growth factor (TGF)-β1, and cyclin-dependent kinases (CDK), is the common feature of glomerulosclerosis. Magnolia officinalis, stem bark of Machilus thunbergii S., has multiple pharmacological effects. In this study, we investigated the influence of aqueous extract of Magnolia officinalis on MC proliferation, DNA synthesis, and expression of PDGF-BB, TGF-β1, CDK1, CDK2, and CDK4 in fetal bovine serum (FBS)-activated human MC. Magnolia officinalis inhibited the MC proliferation, DNA synthesis, and the expression of PDGF-BB, CDK1, and CDK2 gene and CDK1, CDK2, and TGF-β1 protein. These results suggest that the inhibitory effect of Magnolia officinalis on MC proliferation may be mediated by regulation of PDGF-BB and TGF-β1expressions and by modulation of CDK1 and CDK2 expression.

【 授权许可】

Unknown