Roles and Mechanisms of Action of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Growth Hormone and Prolactin Secretion

Endocrine Journal

YOSHIO MURAKAMI¹  JUNKO TANAKA¹  KUNIO KOSHIMURA¹  KATSUMI YAMAUCHI¹  MASATERU NISHIKI¹  YUZURU KATO¹ 

[1]First Division, Department of Medicine, Shimane Medical University

关键词: PrRP;    PRL;    hGR3;    Placenta;    Human;   

DOI  :  10.1507/endocrj.48.123

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(59)Cited-By(2)It appears that PACAP has a direct action on somatotrophs to releaase GH. The intracellular signal transduction mechanisms for PACAP might be similar to but partly distinct from those for GRH. PACAP might play a role in GH secretion induced by serotoninergic mechanisms but not in ultradian rhythm of GH secretion in the rat. PACAP can stimulate PRL release from the pituitary in rats possibly through indirect paracrine effect. In addition, PACAP might participate in regulation of PRL secretion via hypothalamic VIP.

【 授权许可】

Unknown