Repression of Hepatic Cytochrome P450 2D Expression in Mice during Babesia microti Infection

Journal of Veterinary Medical Science

Kensuke WATANABE³  Masashi OKAMURA²  Yoshinori SHIMAMOTO¹  Mayumi ISHIZUKA³  Hiromi IKADAI⁴ 

[1] Department of Veterinary Teaching Hospital, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034�?8628, Japan;Laboratory of Zoonoses, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034�?8628, Japan;Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060�?0818, Japan;Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034�?8628, Japan

关键词: Babesia microti;    CYP2D;    cytochrome P450;   

DOI  :  10.1292/jvms.14-0109

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)To examine the effect of Babesia infection on the level of the drug-metabolizing enzyme hepatic cytochrome P450 (CYP) 2D, we intraperitoneally inoculated Babesia microti into male ICR mice. CYP2D protein and CYP2D9 mRNA were significantly decreased at 12 days after infection with B. microti. The activity of bunitrolol 4-hydroxylase, which is catalyzed by CYP2D, was also significantly decreased. The mRNA levels of transcriptional regulators of CYP2D9, hepatocyte nuclear factor 4α and signal transducer and activator of transcription 5b, were markedly suppressed. These results suggest that Babesia infection represses CYP2D expression in the mouse liver. The decline in CYP2D-dependent drug metabolism might be involved in the incidence of adverse drug reactions in patients with babesiosis.

【 授权许可】

Unknown