Free radicals in skin and muscle: damaging agents or signals for adaptation?

Proceedings of the Nutrition Society

Malcom J. Jackson¹ 

关键词: Antioxidants;    Oxidative stress;    Free radicals;    Skeletal muscle;    Skin;   

DOI  :  10.1017/S0029665199000877

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Much of the current literature regarding the biological effects of antioxidant nutrients has concentrated on their potential role in inhibiting or preventing tissue damage induced by free radical species produced during metabolism. Recent findings indicate that antioxidants may also have more subtle roles, regulating changes in gene expression induced by oxidizing free radical species. There is increasing evidence that free radicals act as signals for cell adaptation in a variety of cell types and the nature of the mechanisms by which free radical species influence gene expression is the subject of much current research. Processes such as these may be particularly important in tissues regularly exposed to varying amounts of oxidative stress as part of their normal physiological functions. Examples of such tissues include skin exposed to u.v. light and skeletal muscle subjected to repeated bouts of exercise.

【 授权许可】

Unknown