Age-Related Changes of Calbindin D-28k-Immunoreactive Neurons in the Myenteric Plexus of Gerbil Duodenum

Journal of Veterinary Medical Science

Je Kyung SEONG²  Dae Won CHUNG²  In Koo HWANG²  In Se LEE²  Moo Ho WON¹  Yeo Sung YOON²  Choong Hyun LEE²  Jung Hoon CHOI² 

[1] Department of Anatomy and Neurobiology, College of Medicine, Hallym Universit;Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University

关键词: aging;    calbindin;    duodenum;    gerbil;    myenteric plexus;   

DOI  :  10.1292/jvms.70.343

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(45)Cited-By(4)We examined the age-related changes of calbindin D-28k (CB)-immunoreactive neurons and overall populations of neurons in the myenteric plexus of gerbil duodenum using whole mount preparations and immunohistochemistry. The circumference of duodenum increased age-dependently. CB-immunoreactive neurons were observed in all groups, and most of them had the Dogiel type II morphology. The fully developed cobweb-like structures were observed in the myenteric plexus of duodenum at postnatal month (PM) 3 to 24. Although the highest numbers of CB-immunoreactive neurons and overall population were observed in PM 1.5, it is related with significant increase of the size of circumference between PM 1.5 to PM 3. CB-immunoreactive neurons were slightly decreased with age between PM 3 to PM 24. We have also found that whole numbers of myenteric neurons were also significantly decreased in PM 24 group. These results suggest that loss of overall numbers of myenteric neurons and CB-immunoreactive neurons may be related with age-related neurodegeneration and functional loss of duodenum in the gerbil.

【 授权许可】

Unknown