期刊论文详细信息
Journal of Veterinary Medical Science
Age-Related Changes of Calbindin D-28k-Immunoreactive Neurons in the Myenteric Plexus of Gerbil Duodenum
Je Kyung SEONG2  Dae Won CHUNG2  In Koo HWANG2  In Se LEE2  Moo Ho WON1  Yeo Sung YOON2  Choong Hyun LEE2  Jung Hoon CHOI2 
[1] Department of Anatomy and Neurobiology, College of Medicine, Hallym Universit;Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
关键词: aging;    calbindin;    duodenum;    gerbil;    myenteric plexus;   
DOI  :  10.1292/jvms.70.343
学科分类:兽医学
来源: Japanese Society of Veterinary Science
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【 摘 要 】

References(45)Cited-By(4)We examined the age-related changes of calbindin D-28k (CB)-immunoreactive neurons and overall populations of neurons in the myenteric plexus of gerbil duodenum using whole mount preparations and immunohistochemistry. The circumference of duodenum increased age-dependently. CB-immunoreactive neurons were observed in all groups, and most of them had the Dogiel type II morphology. The fully developed cobweb-like structures were observed in the myenteric plexus of duodenum at postnatal month (PM) 3 to 24. Although the highest numbers of CB-immunoreactive neurons and overall population were observed in PM 1.5, it is related with significant increase of the size of circumference between PM 1.5 to PM 3. CB-immunoreactive neurons were slightly decreased with age between PM 3 to PM 24. We have also found that whole numbers of myenteric neurons were also significantly decreased in PM 24 group. These results suggest that loss of overall numbers of myenteric neurons and CB-immunoreactive neurons may be related with age-related neurodegeneration and functional loss of duodenum in the gerbil.

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