The Sir David Cuthbertson Medal Lecture Hunting for new pieces to the complex puzzle of obesity: The Annual Meeting of the Nutrition Society and the British Association for Parenteral and Enteral Nutrition was held at The International Centre, Telford on 16–17 November 2005

Proceedings of the Nutrition Society

Gema Frühbeck¹ 

关键词: Obesity;    Aquaporin;    Caveolin;    Comorbidities;    Cardiovascular risk factors;   

DOI  :  10.1079/PNS2006510

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Disentangling the neuroendocrine systems that regulate energy homeostasis andadiposity has been a long-standing challenge in pathophysiology, with obesitybeing an increasingly important public health problem. Adipose tissue is nolonger considered a passive bystander in body-weight regulation. It activelysecretes a large number of hormones, growth factors, enzymes, cytokines,complement factors and matrix proteins, at the same time as expressing receptorsfor most of these elements, which influence fuel storage, mobilisation andutilisation at both central and peripheral sites. Thus, an extensive cross talkat a local and systemic level in response to specific external stimuli ormetabolic changes underpins the multifunctional characteristics of adiposetissue. In addition to the already-known adipokines, such as IL, TNFα,leptin, resistin and adiponectin, more recently attention has been devoted to‘newcomers’ to the ‘adipose tissue arena’, whichinclude aquaporin, caveolin, visfatin, serum amyloid A and vascular endothelialgrowth factor. While in vitro and in vivo experiments have provided extremelyvaluable information, the advances in genomics, proteomics and metabolomics areoffering a level of information not previously attainable to help unlock themolecular basis of obesity. The potential and power of combiningpathophysiological observations with the wealth of information provided by thehuman genome, knock-out models, transgenesis, DNA microarrays, RNA silencing andother emerging technologies offer a new and unprecedented view of a complexdisease, conferring novel insights into old questions by identifying new piecesto the unfinished jigsaw puzzle of obesity.

【 授权许可】

Unknown