Hydrolysis of Extracellular Adenine Nucleotides by Human Spermatozoa: Regulatory Role of Ectonucleotidases in Sperm Function

Croatica Chemica Acta

Romac, Pavle⁴  Vučić, Marijana⁴  Žanić Grubišić, Tihana¹  Ježek, Davor³  Čulić, Ognjen² 

[1] Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska;GlaxoSmithKline Istraživački Centar, Zagreb, Hrvatska;Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska;Sveučilišna bolnica za dijabetes, endokrinološke i metaboličke bolesti Vuk Vrhovec, Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska

关键词: spermatozoa;    ecto-NTPDase;    5';    -nucleotidase;    capacitation;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

Evidence is presented for the existence of ectonucleotidases on the membrane of intact human spermatozoa. Enzymes hydrolyze extracellular ATP, ADP and AMP and hence could be described as ecto-NTPDase and ecto-5'-nucleotidase. Suramin,...

【 授权许可】

Unknown