Effect of d-Pseudoephedrine on Cough Reflex and Its Mode of Action in Guinea Pigs

Journal of Pharmacological Sciences

Hirozo Goto³  Yutaka Shimada³  Akira Haji⁴  Katsutoshi Terasawa²  Kiyoshi Minamizawa³  Yoshiaki Ohi¹ 

[1] Department of Pharmacology, Faculty of Medicine, University of Toyama, Japan;21st Century COE Program, University of Toyama, Japan;Department of Japanese Oriental Medicine, Faculty of Medicine, University of Toyama, Japan;Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, Japan

关键词: d-pseudoephedrine;    antitussive effect;    cough reflex;    nucleus tractus solitarius;    superior laryngeal nerve;   

DOI  :  10.1254/jphs.FP0060526

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(32)Cited-By(4)d-Pseudoephedrine (PSE) is one of the main ingredients of Ephedrae herba. Although PSE is widely applied for patients with a common cold and upper respiratory inflammation as a decongestant, the effects of PSE on cough have never been reported. In this study, we investigated the antitussive effects of intraperitoneal injection of PSE on the cough reflex induced by microinjection of citric acid into the larynx of guinea pigs. PSE decreased the number of cough reflexes dose-dependently (−18.3 ± 5.0% at 20 mg/kg, P<0.05; −41.1 ± 7.2% at 60 mg/kg, P<0.01). Furthermore, PSE (60 mg/kg) increased the threshold intensity for inducing fictive cough by electrical micro-stimulation of the nucleus tractus solitarius (+72.7 ± 8.4%, P<0.01). On the afferent discharge of the superior laryngeal nerve, PSE suppressed the increases of amplitude and frequency when stimulated by citric acid at laryngeal mucosa. These results demonstrate that PSE possesses an antitussive effect that might be derived from both central and peripheral actions.

【 授权许可】

Unknown