Predictive modeling of the hypothalamic-pituitary-adrenal (HPA) axis response to acute and chronic stress

Endocrine Journal

Vladimir M. Markovic²  Ljiljana Kolar-Anic²  Zeljko Cupic³  Vladana Vukojevic¹ 

[1] Department of Clinical Neuroscience, Karolinska Institutet, 17176 Stockholm, Sweden;Faculty of Physical Chemistry, University of Belgrade, 11000 Belgrade, Serbia;Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Department of Catalysis and Chemical Engineering, 11000 Belgrade, Serbia

关键词: HPA axis;    Stress;    Cortisol;    Predictive modeling;    Circadian and ultradian rhythmicity;   

DOI  :  10.1507/endocrj.EJ11-0037

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(60)Cited-By(10)Detailed dynamics of the hypothalamic-pituitary-adrenal (HPA) axis is complex, depending on the individual metabolic load of an organism, its current status (healthy/ill, circadian phase (day/night), ultradian phase) and environmental impact.Therefore, it is difficult to compare the HPA axis activity between different individuals or draw unequivocal conclusions about the overall status of the HPA axis in an individual using single time-point measurements of cortisol levels.The aim of this study is to identify parameters that enable us to compare different dynamic states of the HPA axis and use them to investigate self-regulation mechanisms in the HPA axis under acute and chronic stress.In this regard, a four-dimensional stoichiometric model of the HPA axis was used.Acute stress was modeled by inducing an abrupt change in cortisol level during the course of numerical integration, whereas chronic stress was modeled by changing the mean stationary state concentrations of CRH.Effects of acute stress intensity, duration and time of onset with respect to the ultradian amplitude, ultradian phase and the circadian phase of the perturbed oscillation were studied in detail.Bifurcation analysis was used to predict the response of the HPA axis to chronic stress.Model predictions were compared with experimental findings reported in the literature and relevance for pharmacotherapy with glucocorticoids was discussed.

【 授权许可】

Unknown