Enhanced Learning of Normal Adult Rodents by Repeated Oral Administration of Soybean Transphosphatidylated Phosphatidylserine

Journal of Pharmacological Sciences

Makoto Ukai¹  Tsutomu Kameyama¹  Satoshi Kudo²  Akito Kataoka-Kato²  Masashi Sakai² 

[1] Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University;Yakult Central Institute for Microbiological Research

关键词: phosphatidylserine;    learning;    normal adult rodent;    active avoidance;    brightness discrimination;   

DOI  :  10.1254/jphs.FP0050366

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(35)Cited-By(3)Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) is already known to improve the learning ability of aged or drug-induced amnesic rodents. In this study, its effect on normal adult rodents was evaluated using several learning tasks. Firstly, three behavioral tests (open-field, Y-maze, and active avoidance test) were consecutively carried out after the daily oral administration of SB-tPS (50 mg/kg per day, for 34 days). Repeated oral administration of SB-tPS did not affect either exploratory behavior in the open-field test or spontaneous alternation behavior in the Y-maze test, while mice pretreated with SB-tPS showed significant enhancement of conditioned avoidance response. Secondly, the brightness discrimination test was used to evaluate the effect of SB-tPS on learning ability. The daily oral administration of SB-tPS (50 mg/kg per day, for 27 days) to normal rats significantly increased the correct response ratio in the brightness discrimination test. Finally, to elucidate the necessity of SB-tPS pretreatment, another active avoidance test was carried out, and no enhancement of conditioned avoidance response was observed in non-pretreated mice. These results suggest that repeated administration of SB-tPS could enhance the learning ability of normal adult rodents as those of aged ones.

【 授权许可】

Unknown