Nitric Oxide Plays No Role in ACTH Release Induced by Interleukin-1β, Corticotropin-Releasing Hormone, Arginine Vasopressin and Phorbol Myristate Acetate in Rat Pituitary Cell Cultures

Endocrine Journal

KOZO HASHIMOTO¹  CHISA TOJO¹  TATSUYA NISHIOKA¹  TOSHIHIRO TAKAO¹ 

[1] Second Department of Internal Medicine, Kochi Medical School

关键词: Nitric oxide;    ACTH;    Interleukin-1;    Corticotropin releasing hormone;   

DOI  :  10.1507/endocrj.42.435

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(20)Cited-By(4)To investigate the role of nitric oxide (NO) in pituitary ACTH secretion, the effect of a nitric oxide synthase (NOS) inhibitor, Nω-Nitro-L-arginine (Nitro-Arg), on ACTH secretion induced by interleukin (IL)-1/β, corticotropin releasing hormone (CRH), arginine vasopressin (AVP) and phorbol myristate acetate (PMA) was examined in rat anterior pituitary cell cultures. Nitro-Arg did not affect IL-1β-induced ACTH release in pituitary cell cutures incubated with Dulbecco modified Eagle's medium, Basal Medium Eagle or Krebs Ringer bicarbonate-glucose buffer. It did not affect CRH-, AVP- or PMA-induced ACTH release either. These results suggest that NO does not play an important role in ACTH release at the pituitary level.

【 授权许可】

Unknown