Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey

Brazilian Journal of Infectious Diseases

Tasdemir, Cihan¹  Nakipoglu, Yasar²  Tasdemir, Semiha¹  Ceran, Nurgul¹  Adaleti, Riza¹  Kaya, Fatma¹ 

[1] Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey;Istanbul University, Istanbul, Turkey

关键词: Staphylococcus aureus;    macrolide;    lincosamide;    streptogramin B;    ketolid;    linezolid;    MLSB.;   

DOI  :  10.1590/S1413-86702010000100003

来源: Contexto

【 摘 要 】

The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage of antibiotics. The purpose of this study was to investigate the phenotypic resistance of 321 methicillin resistance Staphylococcus aureus (MRSA) and 195 methicillin susceptible S. aureus (MSSA) in a total of 516 S. aureus strains to macrolide, lincosamide, streptogramin B (MLS_B), ketolid, and linezolid. Disk diffusion method was applied to determine MLS_B phenotype and susceptibility to different antibiotic agents. It was found that 54.6% of the isolates were resistant to erythromycin (ERSA), 48% to clindamycin, 55% to azithromycin, 58.7% to spiramycin, 34.7% to telithromycin, and 0.4% to quinupristin-dalfopristin, respectively. No strain resistant to linezolid was found. The prevalence of constitutive (cMLS_B), inducible (IMLS_B), and macrolides and type B streptogramins (M/MS_B) among ERSA isolates (237 MRSA, 45 MSSA) was 69.6 %, 18.2%, and 12.2 % in MRSA and 28.9%, 40%, and 31.1% in MSSA, respectively. In conclusions, the prevalence of cMLS_B was predominant in MRSA; while in MSSA strains, iMLS_B and M/MS_B phenotype were more higher than cMLS_B phenotype resistance. The resistance to quinupristindalfopristin was very low, and linezolid was considered as the most effective antibiotic against all S.aureus strains.

【 授权许可】

CC BY-NC-ND