Medical Journal of Dr. D.Y. Patil Vidyapeeth | |
Inducible Resistance to Clindamycin in Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Isolated from Clinical Samples in Tertiary Care Hospitals in Guwahati City | |
article | |
Singh, Shila Kumari1  Bhattacharjee, Minakshi1  Unni, Balagopalan2  Kashyap, Rajpal Singh1  | |
[1] Department of Biotechnology, Faculty of Science Assam Downtown University;Research Cell, Assam Downtown University | |
关键词: Clindamycin; D-test; erythromycin; inducible; macrolide–lincosamide; streptogramin B; | |
DOI : 10.4103/mjdrdypu.mjdrdypu_172_21 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Wolters Kluwer Medknow Publications | |
【 摘 要 】
Background: Methicillin-resistant staphylococcus aureus (MRSA) are responsible for many hospital-acquired infections. Clindamycin (CL) is used to treat methicillin-sensitive S. aureus (MSSA) and MRSA. Antibiotic sensitivity testing (AST) can miss out the inducible CL resistance (CL-R) and result in failure of treatment. D-test detects inducible CL-R. Subjects and Methods: One hundred and ten S. aureus strains were tested. D-test was performed using erythromycin (ER) (15 mcg) and CL (2 mcg). The absence of inhibition around ER and a zone of inhibition around CL with flattening of the zone facing ER side is taken as positive D-test. Results: Of the total S. aureus strains, 36% were MRSA and 74% were MSSA. A total of 20 (18.18%) strains out of 110 were found to have inducible CL-R. In this study, MRSA (19.4%) were found to have higher percentage of D-test positivity as compared to MSSA (17.56%). Conclusion: D-test must be performed routinely as a part of AST for the presence of inducible phenotype.
【 授权许可】
CC BY-NC-SA
【 预 览 】
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