Inducible Resistance to Clindamycin in Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Isolated from Clinical Samples in Tertiary Care Hospitals in Guwahati City

Medical Journal of Dr. D.Y. Patil Vidyapeeth

article

Singh, Shila Kumari¹  Bhattacharjee, Minakshi¹  Unni, Balagopalan²  Kashyap, Rajpal Singh¹ 

[1] Department of Biotechnology, Faculty of Science Assam Downtown University;Research Cell, Assam Downtown University

关键词: Clindamycin;    D-test;    erythromycin;    inducible;    macrolide–lincosamide;    streptogramin B;   

DOI  :  10.4103/mjdrdypu.mjdrdypu_172_21

学科分类：社会科学、人文和艺术（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Background:  Methicillin-resistant staphylococcus aureus (MRSA) are responsible for many hospital-acquired infections. Clindamycin (CL) is used to treat methicillin-sensitive S. aureus (MSSA) and MRSA. Antibiotic sensitivity testing (AST) can miss out the inducible CL resistance (CL-R) and result in failure of treatment. D-test detects inducible CL-R. Subjects and Methods:  One hundred and ten S. aureus strains were tested. D-test was performed using erythromycin (ER) (15 mcg) and CL (2 mcg). The absence of inhibition around ER and a zone of inhibition around CL with flattening of the zone facing ER side is taken as positive D-test. Results:  Of the total S. aureus strains, 36% were MRSA and 74% were MSSA. A total of 20 (18.18%) strains out of 110 were found to have inducible CL-R. In this study, MRSA (19.4%) were found to have higher percentage of D-test positivity as compared to MSSA (17.56%). Conclusion:  D-test must be performed routinely as a part of AST for the presence of inducible phenotype.

【 授权许可】

CC BY-NC-SA