Spatial Learning of Mice Lacking a Neuron-Specific Epidermal Growth Factor Family Protein, NELL2

Journal of Pharmacological Sciences

Masato Horie²  Hiroyuki Iso³  Katsuyuki Tanizawa⁵  Naoki Kurihara²  Shun'ichi Kuroda⁵  Nobutaka Doe⁴  Shogo Matsuyama¹ 

[1] Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine;Second Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd.;Department of Behavior Science, Hyogo College of Medicine;Department of Integrated Psychological Science, Kwansei Gakuin University;Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University

关键词: NELL2;    epidermal growth factor;    thrombospondin;    hippocampus;    spatial learning;   

DOI  :  10.1254/jphs.FP0050211

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(26)Cited-By(12)NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains. We previously disrupted the NELL2 gene in mice by gene targeting and showed that long-term potentiation is enhanced in vivo in the dentate gyrus of NELL2-deficient mice. To further elucidate the physiological roles of NELL2, we performed a behavioral characterization of NELL2−/− and their heterozygous control mice. NELL2-deficient mice exhibited learning impairment in the Morris water maze task. However, we observed no difference in passive avoidance learning between NELL2−/− and NELL2+/− mice. These observations suggest that NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2.

【 授权许可】

Unknown