Journal of Veterinary Medical Science | |
Immunohistochemical Detection of Phosphatidylserine and Thrombospondin on Denucleating Erythroblasts in Rat Bone Marrow | |
Eiichiro TAKAHARA1  Takanori MIKI3  Yoshiki TAKEUCHI3  Takahiko ETOH2  Yoshiki MATSUMOTO3  Wang-Mei QI2  Nobuhiko HOSHI1  Kankanam Gamage Sanath UDAYANGA1  Hiroshi KITAGAWA1  Katsuhiko WARITA3  Toshifumi YOKOYAMA1  | |
[1] Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University;Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University;Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University | |
关键词: apoptosis; denucleation; erythropoiesis; phosphatidylserine; thrombospondin; | |
DOI : 10.1292/jvms.10-0437 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(24)The hypothesis that apoptotic factors play some roles in the denucleation of erythroblasts has been confirmed by the immunohistological detection of both phosphatidylserine and thrombospondin as phagocytosis-inducing factors in general apoptotic events. Both phosphatidylserine and thrombospondin were detected on the surface of cell membrane of mature erythroblasts, while thrombospondin was also detected in more immature erythroblasts. The intensities of their immune reactions increased as the erythroids matured. During denucleation, the positivities of both phosphatidylserine and thrombospondin were restricted on the surface of the cell membrane surrounding the protruding nuclei. Thus, the apoptotic process involves denucleation of erythroblasts and phosphatidylserine, and thrombospondin acts as phagocytosis-inducing factors in the denucleation event.
【 授权许可】
Unknown
【 预 览 】
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