Treatment of Microcotyle sebastis infestationin cultured rockfish Sebastes schlegeli by oral administration of praziquantel in combination with cimetidine

Diseases of Aquatic Organisms

Eun Hae Lee¹  Jae Bum Cho¹  Ki Hong Kim¹  Se Ryun Kwon¹ 

关键词: Praziquantel;    Cimetidine;    Microcotyle sebastis;    Sebastes schlegeli;    Treatment efficacy;   

DOI  :  10.3354/dao044133

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: The effect of cimetidine on the treatment efficacy of praziquantel against Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli was investigated. Juvenile rockfish were divided into 7 groups, and orallyadministered praziquantel alone (50, 100 and 200 mg kg^-1 body wt, BW) or in combination with cimetidine at a dose of 200 mg kg^-1 BW for each praziquantel dose. The fish in the control group were administered only saline. The resultsclearly showed that coadministration of cimetidine with praziquantel led to a significantly increased treatment efficacy of the latter drug, and consequently would lead to a lowering of the total dose of praziquantel, and a reduction in the administrationtimes and costs for the treatment of M. sebastis infestation in cultured rockfish.

【 授权许可】

Unknown