Anti-atherogenic Actions of High-density Lipoprotein through Sphingosine 1-Phosphate Receptors and Scavenger Receptor Class B Type I

Endocrine Journal

Koichi SATO¹  Takao KIMURA²  Fumikazu OKAJIMA¹ 

[1] Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University;Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine

关键词: High-density lipoprotein;    Apolipoprotein A-I;    Sphingosine 1-phosphate;    Scavenger receptor class B type I;   

DOI  :  10.1507/endocrj.K08E-228

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(132)Cited-By(15)Plasma high-density lipoprotein (HDL) is a potent anti-atherogenic factor, a critical role of which is thought to be reverse cholesterol transport through the lipoprotein-associated apolipoprotein A-I (apoA-I). HDL also carries a potent bioactive lipid mediator, sphingosine 1-phophate (S1P), which exerts diverse physiological and pathophysiological actions in a variety of biological systems, including the cardiovascular system. In addition, HDL-associated apoA-I is known to stimulate intracellular signaling pathways unrelated to transporter activity. Mounting evidence indicates that multiple antiatherogenic or anti-inflammatory actions of HDL independent of cholesterol metabolism are mediated by the lipoproteinassociated S1P through S1P receptors and by apoA-I through scavenger receptor class B type I.

【 授权许可】

Unknown