Flow Cytometric Analysis of Thymocyte Subpopulations in Mice after Whole-Body X-Irradiation

Journal of Veterinary Medical Science

Kihei Kubo¹  Satoshi Matsuyama¹  Yasuhiko Takamori¹  Shuntaro Oka¹ 

[1] Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan

关键词: cell surface antigen;    murine thymocyte;    X-irradiation;   

DOI  :  10.1292/jvms.61.709

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(3)To determined the cellular kinetics of thymocyte subpopulations in DBA1 mice after whole-body 6.8 Gy X-irradiation, they were analyzed for the expression of several cell surface antigens using flow cytometry. The results show that i) The majority of thymocytes rapidly depleted by irradiation was CD4+8+ cells. ii) radioresistant CD4+8- and CD4-8+ survived 18-48 hr after X-irradiation were considered to be relatively mature type, since they expressed high levels of CD3 and LECAM-1. iii) CD3-positive cells were detected in CD4-8- cells at 72 hr after irradiation.

【 授权许可】

Unknown