Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

Endocrine Journal

Masato KIMURA³  Mayumi TSUJI³  Tetsuyuki YASUDA¹  Munehide MATSUHISA¹  Noriko FUJISAWA³  Noritaka FUJIKI³  Hideaki KANETO¹  Eiichi IMANO³  Yoshimitsu YAMASAKI¹  Rieko ISHIBASHI³  Fumie SAKAMOTO³  Takao WATARAI² 

[1] Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine;Department of Nutrition, Koshien University;Department of Internal Medicine, Osaka Kosei-Nenkin Hospital

关键词: Metabolic syndrome;    Central obesity;    Diabetes;    Carotid atherosclerosis;   

DOI  :  10.1507/endocrj.K06-210

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(32)Cited-By(10)Metabolic syndrome has been revealed to be a major risk factor for cardiovascular disease (CVD) and early mortality in non-diabetic and diabetic patients. In 2005, the International Diabetes Federation (IDF) and the Examination Committee of Criteria for Diagnosis of Metabolic Syndrome in Japan published new definitions of metabolic syndrome in which central obesity was an indispensable factor. However, the significance of this new definition to CVD in type 2 diabetes has not yet been clarified. A cross-sectional study was conducted with 294 Japanese type 2 diabetic patients without known cardiovascular disease to evaluate the association between metabolic syndrome defined by this new definition and carotid atherosclerosis, and the significance of central obesity for the prediction of the development of carotid atherosclerosis. In a multivariate regression analysis, metabolic syndrome but not central obesity was significantly associated with carotid intima-media thickness (IMT) independent of known cardiovascular risk factors (p<0.05). In addition, whereas carotid IMT was significantly increased according to the increase in the number of components of metabolic syndrome, it was not significantly different between the groups with the same number of components of metabolic syndrome with or without central obesity. These findings suggest that the prediction of the development of carotid atherosclerosis in Japanese type 2 diabetic patients could be improved by the assessment of aggregation of components of metabolic syndrome rather than with or without metabolic syndrome by this new definition.

【 授权许可】

Unknown