The value of the apoB/apoAl ratio and the non-HDL-C/HDL-C ratio in predicting carotid atherosclerosis among Chinese individuals with metabolic syndrome: a cross-sectional study

卷:14

Qin, Guangming ; Tu, Jiangfeng ; Zhang, Chenjing ; Tang, Xiaoxiao ; Luo, Laisheng ; Wu, Jiaqi ; Liu, Lingang ; Lu, Wen ; Tao, Lisha ; Shen, Shengrong ; Das, Undurti N. ; Pan, Wensheng

关键词: Carotid atherosclerosis;    Carotid intima-media thickness;    Metabolic syndrome;    ApoB/apoAl;    Non-HDL-C/HDL-C;   

DOI  :  10.1186/s12944-015-0023-4

学科分类：食品科学和技术

【 摘 要 】

Background: Metabolic syndrome (MetS) is associated with carotid intima-media thickness (CIMT), which is a good predictor of cardiovascular disease (CVD). However, among individuals with MetS, direct comparative data regarding the utility of the apoB/apoAl ratio and the non-HDL-C/HDL-C ratio to diagnose carotid atherosclerosis are scarce, particularly in Chinese populations. We aimed to determine the relationship between the apoB/apoAl ratio and the non-HDL-C/HDL-C ratio and carotid atherosclerosis among Chinese individuals with MetS. Methods: We performed a retrospective study of 5822 Chinese participants who underwent a routine health screening examination. Lipid profiles, fasting glucose, fasting insulin, CRP, apoB, apoAl and CIMT were measured. Results: We observed that among Chinese individuals with MetS, men (53.95 +/- 0.58 ys) developed carotid atherosclerosis at a younger age than women (58.47 +/- 1.17 ys) (P < 0.001). Both the apoB/apoAl ratio and the non-HDL-C/HDL-C ratio positively correlated with carotid atherosclerosis among Chinese individuals with MetS, particularly among women. Meanwhile, CIMT increased progressively across the quartiles of the non-HDL-C/HDL-C ratio (P for trend, < 0.05). Receiver Operating Characteristic (ROC) analysis indicated that the AUC of the apoB/apoAl ratio (0.561) was higher than that of the non-HDL-C/HDL-C ratio (0.522) in men (P < 0.05) and the AUC of the apoB/apoAl ratio (0.640) was lower than that of the non-HDL-C/HDL-C ratio (0.695) in women (P < 0.05). Among Chinese individuals with MetS, the AUC of the non-HDL-C/HDL-C ratio was more prominent among women compared with men (P < 0.05). Conclusion: Our findings indicate that among individuals with MetS, Chinese men develop carotid atherosclerosis at a much younger age than women. There were no significant differences between the apoB/apoAl ratio and the non-HDL-C/HDL-C ratio for the prediction of carotid atherosclerosis among Chinese individuals with MetS. Among Chinese individuals with MetS, the utility of the non-HDL-C/HDL-C ratio was found to be greater among women than among men.