Growth of Two Children after Six Months Interruption of GH Therapy

Endocrine Journal

KAZUIE IINUMA¹  IKUMA FUJIWARA¹  AKI ASANUMA¹  EISHIN OGAWA¹  YURIKO KATSUSHIMA¹ 

[1] Department of Pediatrics, Tohoku University School of Medicine

关键词: Growth;    GH therapy;    Interruption;   

DOI  :  10.1507/endocrj.46.Suppl_S43

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(2)We describe two short boys with normal GH responses to the stimuli in whom GH therapy was interrupted for 6 months. Their growth rates before and after the interruption, and after readministration of GH were evaluated. Height velocity (HV) in case 1 before and after the interruption was 6.6cm/y and 5.0cm/y, respectively. HV was not increased (5.0cm/y) by re-initiation of GH therapy despite the high serum IGF-1 level. Height velocity (HV) in case 2 before and after the interruption was 5.6cm/y and 3.6cm/y, respectively. HV was slightly increased to 4.1cm/y by readministration of GH, but it was far below the pretreatment value. Serum IGF-1 was increased by GH in this case as well. We conclude that re-acceleration of growth by re-administration of GH after interruption of therapy, as seen in classical GHD patients, may not be expected in normal short children.

【 授权许可】

Unknown