A Patient of Short Stature with Normal GH Secretion, but a Low Serum IGF-I Level

Endocrine Journal

MASAYUKI KAJI¹  HIROKO KODAMA²  MASAAKI KOBAYASHI²  DAISHI MOCHIZUKI²  NATSUE NAKAMOTO²  KAZUOMI KUBOTA²  YUKISHIGE YANAGAWA²  YOSUKE MORI² 

[1] Division of Endocrinology and Metabolism, Shizuoka Children';s Hospital;Department of Pediatrics, Teikyo University School of Medicine

关键词: Short Stature;    Normal GH secretion;    Low serum IGF-I;    GH-1 gene;    GH therapy;   

DOI  :  10.1507/endocrj.47.SupplMarch_S125

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(5)We report the case of a 7-year-old patient of short stature who had normal GH secretion, but a very low serum IGF-I level. On admittance, his height and weight were 102.2cm (-3.8S.D.) and 15.7kg (-1.8S.D)., respectively. His bone age was 2 years and 8 months. The serum GH responses to insulin, glucagon and L-dopa were all normal. GH secretion during sleep was also normal, but the serum IGF-I level was very low (29ng/ml). The serum IGF-I level was greatly increased by the administration of GH. No mutation was detected in the GH-1 gene. His height velocity was noticeably improved by GH treatment.

【 授权许可】

Unknown