Intestinal Undifferentiated Carcinoma in a Red-Crowned Crane (Grus japonensis)

Journal of Veterinary Medical Science

Hiroyuki TANIYAMA²  Minoru OKAMOTO²  Kazuko HIRAYAMA²  Kazuya MATSUDA²  Ryoji SHIMURA¹  Shinobu IKOMA¹  Hiroko IIMA¹  Kanako SAKAGUCHI² 

[1] Kushiro Zoo, 11 Shimo-ninishibetsu Akan-cho, Kushiro, Hokkaido 085–0201, Japan;Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069–8501, Japan

关键词: immunohistochemistry;    red-crowned crane;    undifferentiated carcinoma;   

DOI  :  10.1292/jvms.12-0438

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)A 33-year-old red-crowned crane (Grus japonensis) had a diffuse intestinal thickening from the duodenum to colon. Microscopically, neoplastic cells were arranged in sheets and occasionally nests or cords without gland or squamous differentiation. Metastatic tumor cells were found in the lungs, heart, kidneys and adrenal glands. Immunohistochemically, the neoplastic cells were strongly positive for pan-cytokeratin and cytokeratin 8 and 18 and only partly positive for E-cadherin antibodies. Immunostaining for CD3 was positive in normal lymphocytes, and NSE was also positive in normal nerve fibers. But, the neoplastic cells were not immunoreactive to CD3 and NSE. Based on the histological features and the epithelial characteristics in the immunohistochemical stain, the present case was diagnosed as undifferentiated carcinoma originating from the intestine. Interestingly, the neoplastic cells showed a unique growth pattern; they never invaded the submucosa or muscularis throughout the intestine, whereas they spread lymphogenously or hematogenously to other organs.

【 授权许可】

Unknown