Journal of Pharmacological Sciences | |
Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament | |
Toshiyuki Sasaguri2  Fumi Takahashi-Yanaga2  Yoshikazu Miwa2  Sachio Morimoto2  Naoto Tadano2  Iwao Ohtsuki1  | |
[1] Depertment of Physiology, The Jikei University School of Medicine, Japan;Depertment of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan | |
关键词: propyl gallate; Ca2+ sensitizer; antioxidant; | |
DOI : 10.1254/jphs.08266SC | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(12)Cited-By(2)Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation in cardiac muscle fibers. We found that propyl gallate, a strong antioxidant, increased the Ca2+ sensitivity of cardiac myofilament in a dose-dependent and reversible manner. The present study indicates that propyl gallate is a novel type of Ca2+ sensitizer with antioxidant activity, which might be more beneficial for the treatment of congestive heart failure associated with oxidative stress than existing Ca2+ sensitizers.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300483135ZK.pdf | 325KB | download |