Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament

Journal of Pharmacological Sciences

Toshiyuki Sasaguri²  Fumi Takahashi-Yanaga²  Yoshikazu Miwa²  Sachio Morimoto²  Naoto Tadano²  Iwao Ohtsuki¹ 

[1] Depertment of Physiology, The Jikei University School of Medicine, Japan;Depertment of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan

关键词: propyl gallate;    Ca2+ sensitizer;    antioxidant;   

DOI  :  10.1254/jphs.08266SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(2)Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation in cardiac muscle fibers. We found that propyl gallate, a strong antioxidant, increased the Ca2+ sensitivity of cardiac myofilament in a dose-dependent and reversible manner. The present study indicates that propyl gallate is a novel type of Ca2+ sensitizer with antioxidant activity, which might be more beneficial for the treatment of congestive heart failure associated with oxidative stress than existing Ca2+ sensitizers.

【 授权许可】

Unknown