Insights Into Sepsis Therapeutic Design Based on the Apoptotic Death Pathway

Journal of Pharmacological Sciences

Ken-ichi Takano²  Yuichi Hattori²  Hiroki Yokoo²  Seiji Yamamoto²  Hiroki Teramae¹  Naoyuki Matsuda¹ 

[1] Department of Emergency & Critical Care Medicine, Nagoya University Graduate School of Medicine, Japan;Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

关键词: sepsis;    apoptosis;    death receptor;    acute lung injury;    endothelial cell;    gene therapy;   

DOI  :  10.1254/jphs.10R04CR

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(108)Cited-By(20)Sepsis remains the leading cause of death in critically ill patients. A major problem contributing to sepsis-related high mortality is the lack of effective medical treatment. Thus, the key goal in critical care medicine is to develop novel therapeutic strategies that will impact favorably on septic patient outcome. While it is generally accepted that sepsis is an inflammatory state resulting from the systemic response to infection, apoptosis is implicated to be an important mechanism of the death of lymphocytes, gastrointestinal and lung epithelial cells, and vascular endothelial cells associated with the development of multiple organ failure in sepsis. The pivotal role of cell apoptosis is now highlighted by multiple studies demonstrating that prevention of cell apoptosis can improve survival in clinically relevant animal models of sepsis. In this review article, we address the scientific rationale for remedying apoptotic cell death in sepsis and propose that therapeutic efforts aimed at blocking cell signaling pathways leading to apoptosis may represent an attractive target for sepsis therapy.

【 授权许可】

Unknown